Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells
Identifieur interne : 001518 ( Main/Exploration ); précédent : 001517; suivant : 001519Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells
Auteurs : Seog-Young Kim [États-Unis] ; Dae-Hee Lee [États-Unis] ; Xinxin Song [États-Unis] ; David L. Bartlett [États-Unis] ; Yong Tae Kwon [Corée du Sud] ; Yong J. Lee [États-Unis]Source :
- Apoptosis [ 1360-8185 ] ; 2014.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Antibiotiques antinéoplasiques (pharmacologie), Apoptose, Bécline-1, Cytochromes c (métabolisme), Humains, Hyperthermie provoquée, Ligand TRAIL (génétique), Ligand TRAIL (métabolisme), Lignée cellulaire tumorale, MAP Kinase Kinase 4 (métabolisme), Mitochondries (métabolisme), Mitomycine (pharmacologie), Multimérisation de protéines, Protéine Bak (métabolisme), Protéine bcl-X (métabolisme), Protéines membranaires (métabolisme), Protéines régulatrices de l'apoptose (métabolisme), Tumeurs du côlon (anatomopathologie), Tumeurs du côlon (métabolisme), Vecteurs génétiques.
- MESH :
- anatomopathologie : Tumeurs du côlon.
- génétique : Adenoviridae, Ligand TRAIL.
- métabolisme : Cytochromes c, Ligand TRAIL, MAP Kinase Kinase 4, Mitochondries, Protéine Bak, Protéine bcl-X, Protéines membranaires, Protéines régulatrices de l'apoptose, Tumeurs du côlon.
- pharmacologie : Antibiotiques antinéoplasiques, Mitomycine.
- Apoptose, Bécline-1, Humains, Hyperthermie provoquée, Lignée cellulaire tumorale, Multimérisation de protéines, Vecteurs génétiques.
English descriptors
- KwdEn :
- Adenoviridae (genetics), Antibiotics, Antineoplastic (pharmacology), Apoptosis, Apoptosis Regulatory Proteins (metabolism), Beclin-1, Cell Line, Tumor, Colonic Neoplasms (metabolism), Colonic Neoplasms (pathology), Cytochromes c (metabolism), Genetic Vectors, Humans, Hyperthermia, Induced, MAP Kinase Kinase 4 (metabolism), Membrane Proteins (metabolism), Mitochondria (metabolism), Mitomycin (pharmacology), Protein Multimerization, TNF-Related Apoptosis-Inducing Ligand (genetics), TNF-Related Apoptosis-Inducing Ligand (metabolism), bcl-2 Homologous Antagonist-Killer Protein (metabolism), bcl-X Protein (metabolism).
- MESH :
- chemical , genetics : TNF-Related Apoptosis-Inducing Ligand.
- chemical , metabolism : Apoptosis Regulatory Proteins, Cytochromes c, MAP Kinase Kinase 4, Membrane Proteins, TNF-Related Apoptosis-Inducing Ligand, bcl-2 Homologous Antagonist-Killer Protein, bcl-X Protein.
- chemical , pharmacology : Antibiotics, Antineoplastic, Mitomycin.
- genetics : Adenoviridae.
- metabolism : Colonic Neoplasms, Mitochondria.
- pathology : Colonic Neoplasms.
- Apoptosis, Beclin-1, Cell Line, Tumor, Genetic Vectors, Humans, Hyperthermia, Induced, Protein Multimerization.
Abstract
In this study, we attempted to develop a multimodality approach using chemotherapeutic agent mitomycin C, biologic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L), and mild hyperthermia to treat colon cancer. For this study, human colon cancer LS174T, LS180, HCT116 and CX-1 cells were infected with secretory TRAIL-armed adenovirus (Ad.TRAIL) and treated with chemotherapeutic agent mitomycin C and hyperthermia. The combinatorial treatment caused a synergistic induction of apoptosis which was mediated through an increase in caspase activation. The combinational treatment promoted the JNK-Bcl-xL-Bak pathway which transmitted the synergistic effect through the mitochondria-dependent apoptotic pathway. JNK signaling led to Bcl-xL phosphorylation at serine 62, dissociation of Bak from Bcl-xL, oligomerization of Bak, alteration of mitochondrial membrane potential, and subsequent cytochrome
Url:
DOI: 10.1007/s10495-014-1028-6
PubMed: 25156145
PubMed Central: 4196052
Affiliations:
- Corée du Sud, États-Unis
- Pennsylvanie, Région capitale de Séoul
- Pittsburgh, Séoul
- Université de Pittsburgh, Université nationale de Séoul
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Le document en format XML
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secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells</title><author><name sortKey="Kim, Seog Young" sort="Kim, Seog Young" uniqKey="Kim S" first="Seog-Young" last="Kim">Seog-Young Kim</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA 15213 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Dae Hee" sort="Lee, Dae Hee" uniqKey="Lee D" first="Dae-Hee" last="Lee">Dae-Hee Lee</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA 15213 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Song, Xinxin" sort="Song, Xinxin" uniqKey="Song X" first="Xinxin" last="Song">Xinxin Song</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA 15213 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Bartlett, David L" sort="Bartlett, David L" uniqKey="Bartlett D" first="David L." last="Bartlett">David L. Bartlett</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA 15213 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Kwon, Yong Tae" sort="Kwon, Yong Tae" uniqKey="Kwon Y" first="Yong Tae" last="Kwon">Yong Tae Kwon</name><affiliation wicri:level="4"><nlm:aff id="Aff3">Protein Metabolism Medical Research Center and Department of Biomedical Science, College of Medicine, Seoul National University, Seoul, 110-799 Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Protein Metabolism Medical Research Center and Department of Biomedical Science, College of Medicine, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Lee, Yong J" sort="Lee, Yong J" uniqKey="Lee Y" first="Yong J." last="Lee">Yong J. Lee</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA 15213, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh, PA 15213 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, School of Medicine, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Ave. Room 1.46C, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Apoptosis</title><idno type="ISSN">1360-8185</idno><idno type="eISSN">1573-675X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term><term>Antibiotics, Antineoplastic (pharmacology)</term><term>Apoptosis</term><term>Apoptosis Regulatory Proteins (metabolism)</term><term>Beclin-1</term><term>Cell Line, Tumor</term><term>Colonic Neoplasms (metabolism)</term><term>Colonic Neoplasms (pathology)</term><term>Cytochromes c (metabolism)</term><term>Genetic Vectors</term><term>Humans</term><term>Hyperthermia, Induced</term><term>MAP Kinase Kinase 4 (metabolism)</term><term>Membrane Proteins (metabolism)</term><term>Mitochondria (metabolism)</term><term>Mitomycin (pharmacology)</term><term>Protein Multimerization</term><term>TNF-Related Apoptosis-Inducing Ligand (genetics)</term><term>TNF-Related Apoptosis-Inducing Ligand (metabolism)</term><term>bcl-2 Homologous Antagonist-Killer Protein (metabolism)</term><term>bcl-X Protein (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Antibiotiques antinéoplasiques (pharmacologie)</term><term>Apoptose</term><term>Bécline-1</term><term>Cytochromes c (métabolisme)</term><term>Humains</term><term>Hyperthermie provoquée</term><term>Ligand TRAIL (génétique)</term><term>Ligand TRAIL (métabolisme)</term><term>Lignée cellulaire tumorale</term><term>MAP Kinase Kinase 4 (métabolisme)</term><term>Mitochondries (métabolisme)</term><term>Mitomycine (pharmacologie)</term><term>Multimérisation de protéines</term><term>Protéine Bak (métabolisme)</term><term>Protéine bcl-X (métabolisme)</term><term>Protéines membranaires (métabolisme)</term><term>Protéines régulatrices de l'apoptose (métabolisme)</term><term>Tumeurs du côlon (anatomopathologie)</term><term>Tumeurs du côlon (métabolisme)</term><term>Vecteurs génétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>TNF-Related Apoptosis-Inducing Ligand</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apoptosis Regulatory Proteins</term><term>Cytochromes c</term><term>MAP Kinase Kinase 4</term><term>Membrane Proteins</term><term>TNF-Related Apoptosis-Inducing Ligand</term><term>bcl-2 Homologous Antagonist-Killer Protein</term><term>bcl-X Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibiotics, Antineoplastic</term><term>Mitomycin</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du côlon</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Ligand TRAIL</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Colonic Neoplasms</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytochromes c</term><term>Ligand TRAIL</term><term>MAP Kinase Kinase 4</term><term>Mitochondries</term><term>Protéine Bak</term><term>Protéine bcl-X</term><term>Protéines membranaires</term><term>Protéines régulatrices de l'apoptose</term><term>Tumeurs du côlon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colonic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibiotiques antinéoplasiques</term><term>Mitomycine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term><term>Beclin-1</term><term>Cell Line, Tumor</term><term>Genetic Vectors</term><term>Humans</term><term>Hyperthermia, Induced</term><term>Protein Multimerization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term><term>Bécline-1</term><term>Humains</term><term>Hyperthermie provoquée</term><term>Lignée cellulaire tumorale</term><term>Multimérisation de protéines</term><term>Vecteurs génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, we attempted to develop a multimodality approach using chemotherapeutic agent mitomycin C, biologic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L), and mild hyperthermia to treat colon cancer. For this study, human colon cancer LS174T, LS180, HCT116 and CX-1 cells were infected with secretory TRAIL-armed adenovirus (Ad.TRAIL) and treated with chemotherapeutic agent mitomycin C and hyperthermia. The combinatorial treatment caused a synergistic induction of apoptosis which was mediated through an increase in caspase activation. The combinational treatment promoted the JNK-Bcl-xL-Bak pathway which transmitted the synergistic effect through the mitochondria-dependent apoptotic pathway. JNK signaling led to Bcl-xL phosphorylation at serine 62, dissociation of Bak from Bcl-xL, oligomerization of Bak, alteration of mitochondrial membrane potential, and subsequent cytochrome <italic>c</italic> release. Overexpression of dominant-negative mutant of Bcl-xL (S62A), but not dominant-positive mutant of Bcl-xL (S62D), suppressed the synergistic death effect. Interestingly, Beclin-1 was dissociated from Bcl-xL and overexpression of dominant-negative mutant of Bcl-xL (S62A), but not dominant-positive mutant of Bcl-xL (S62D), suppressed dissociation of Beclin-1 from Bcl-xL. A combinatorial treatment of mitomycin C, Ad.TRAIL and hyperthermia induced Beclin-1 cleavage, but the Beclin-1 cleavage was abolished in Beclin-1 double mutant (D133A/D146A) knock-in HCT116 cells, suppressing the apoptosis induced by the combination therapy. We believe that this study supports the application of the multimodality approach to colon cancer therapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chua, Tc" uniqKey="Chua T">TC Chua</name></author><author><name sortKey="Esquivel, J" uniqKey="Esquivel J">J Esquivel</name></author><author><name sortKey="Pelz, Jo" uniqKey="Pelz J">JO Pelz</name></author><author><name sortKey="Morris, Dl" uniqKey="Morris D">DL Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saltz, Lb" uniqKey="Saltz L">LB Saltz</name></author><author><name sortKey="Cox, Jv" uniqKey="Cox J">JV Cox</name></author><author><name sortKey="Blanke, C" uniqKey="Blanke C">C Blanke</name></author><author><name sortKey="Rosen, Ls" uniqKey="Rosen L">LS Rosen</name></author><author><name sortKey="Fehrenbacher, L" uniqKey="Fehrenbacher L">L Fehrenbacher</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Maroun, Ja" uniqKey="Maroun J">JA Maroun</name></author><author><name sortKey="Ackland, Sp" uniqKey="Ackland S">SP Ackland</name></author><author><name sortKey="Locker, Pk" uniqKey="Locker P">PK Locker</name></author><author><name sortKey="Pirotta, N" uniqKey="Pirotta N">N Pirotta</name></author><author><name sortKey="Elfring, Gl" uniqKey="Elfring G">GL Elfring</name></author><author><name sortKey="Miller, Ll" uniqKey="Miller L">LL Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurwitz, H" uniqKey="Hurwitz H">H Hurwitz</name></author><author><name sortKey="Fehrenbacher, L" uniqKey="Fehrenbacher L">L Fehrenbacher</name></author><author><name sortKey="Novotny, W" uniqKey="Novotny W">W Novotny</name></author><author><name sortKey="Cartwright, T" uniqKey="Cartwright T">T Cartwright</name></author><author><name sortKey="Hainsworth, J" uniqKey="Hainsworth J">J Hainsworth</name></author><author><name sortKey="Heim, W" uniqKey="Heim W">W Heim</name></author><author><name sortKey="Berlin, J" uniqKey="Berlin J">J Berlin</name></author><author><name sortKey="Baron, A" uniqKey="Baron A">A Baron</name></author><author><name sortKey="Griffing, S" uniqKey="Griffing S">S Griffing</name></author><author><name sortKey="Holmgren, E" uniqKey="Holmgren E">E Holmgren</name></author><author><name sortKey="Ferrara, N" uniqKey="Ferrara N">N Ferrara</name></author><author><name sortKey="Fyfe, G" uniqKey="Fyfe G">G Fyfe</name></author><author><name sortKey="Rogers, B" uniqKey="Rogers B">B Rogers</name></author><author><name sortKey="Ross, R" uniqKey="Ross R">R Ross</name></author><author><name sortKey="Kabbinavar, F" uniqKey="Kabbinavar F">F Kabbinavar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colucci, G" uniqKey="Colucci G">G Colucci</name></author><author><name sortKey="Gebbia, V" uniqKey="Gebbia V">V Gebbia</name></author><author><name sortKey="Paoletti, G" uniqKey="Paoletti G">G Paoletti</name></author><author><name sortKey="Giuliani, F" uniqKey="Giuliani F">F Giuliani</name></author><author><name sortKey="Caruso, M" uniqKey="Caruso M">M Caruso</name></author><author><name sortKey="Gebbia, N" uniqKey="Gebbia N">N Gebbia</name></author><author><name sortKey="Carteni, G" uniqKey="Carteni G">G Cartenì</name></author><author><name sortKey="Agostara, B" uniqKey="Agostara B">B Agostara</name></author><author><name sortKey="Pezzella, G" uniqKey="Pezzella G">G Pezzella</name></author><author><name sortKey="Manzione, L" uniqKey="Manzione L">L Manzione</name></author><author><name sortKey="Borsellino, N" uniqKey="Borsellino N">N Borsellino</name></author><author><name sortKey="Misino, A" uniqKey="Misino A">A Misino</name></author><author><name sortKey="Romito, S" uniqKey="Romito S">S Romito</name></author><author><name sortKey="Durini, E" uniqKey="Durini E">E Durini</name></author><author><name sortKey="Cordio, S" uniqKey="Cordio S">S Cordio</name></author><author><name sortKey="Di Seri, M" uniqKey="Di Seri M">M Di Seri</name></author><author><name sortKey="Lopez, M" uniqKey="Lopez M">M Lopez</name></author><author><name sortKey="Maiello, E" uniqKey="Maiello E">E Maiello</name></author><author><name sortKey="Montemurro, S" uniqKey="Montemurro S">S Montemurro</name></author><author><name sortKey="Cramarossa, A" uniqKey="Cramarossa A">A Cramarossa</name></author><author><name sortKey="Lorusso, V" uniqKey="Lorusso V">V Lorusso</name></author><author><name sortKey="Di Bisceglie, M" uniqKey="Di Bisceglie M">M Di Bisceglie</name></author><author><name sortKey="Chiarenza, M" uniqKey="Chiarenza M">M Chiarenza</name></author><author><name sortKey="Valerio, Mr" uniqKey="Valerio M">MR Valerio</name></author><author><name sortKey="Guida, T" uniqKey="Guida T">T Guida</name></author><author><name sortKey="Leonardi, V" uniqKey="Leonardi V">V Leonardi</name></author><author><name sortKey="Pisconti, S" uniqKey="Pisconti S">S Pisconti</name></author><author><name sortKey="Rosati, G" uniqKey="Rosati G">G Rosati</name></author><author><name sortKey="Carrozza, F" uniqKey="Carrozza F">F Carrozza</name></author><author><name sortKey="Nettis, G" uniqKey="Nettis G">G Nettis</name></author><author><name sortKey="Valdesi, M" uniqKey="Valdesi M">M Valdesi</name></author><author><name sortKey="Filippelli, G" uniqKey="Filippelli G">G Filippelli</name></author><author><name sortKey="Fortunato, S" uniqKey="Fortunato S">S Fortunato</name></author><author><name sortKey="Mancarella, S" uniqKey="Mancarella S">S Mancarella</name></author><author><name sortKey="Brunetti, C" uniqKey="Brunetti C">C Brunetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cassidy, J" uniqKey="Cassidy J">J Cassidy</name></author><author><name sortKey="Clarke, S" uniqKey="Clarke S">S Clarke</name></author><author><name sortKey="Diaz Rubio, E" uniqKey="Diaz Rubio E">E Díaz-Rubio</name></author><author><name sortKey="Scheithauer, W" uniqKey="Scheithauer W">W Scheithauer</name></author><author><name sortKey="Figer, A" uniqKey="Figer A">A Figer</name></author><author><name sortKey="Wong, R" uniqKey="Wong R">R Wong</name></author><author><name sortKey="Koski, S" uniqKey="Koski S">S Koski</name></author><author><name sortKey="Lichinitser, M" uniqKey="Lichinitser M">M Lichinitser</name></author><author><name sortKey="Yang, Ts" uniqKey="Yang T">TS Yang</name></author><author><name sortKey="Rivera, F" uniqKey="Rivera F">F Rivera</name></author><author><name sortKey="Couture, F" uniqKey="Couture F">F Couture</name></author><author><name sortKey="Sirzen, F" uniqKey="Sirzen F">F Sirzén</name></author><author><name sortKey="Saltz, L" uniqKey="Saltz L">L Saltz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porschen, R" uniqKey="Porschen R">R Porschen</name></author><author><name sortKey="Arkenau, Ht" uniqKey="Arkenau H">HT Arkenau</name></author><author><name sortKey="Kubicka, S" uniqKey="Kubicka S">S Kubicka</name></author><author><name sortKey="Greil, R" uniqKey="Greil R">R Greil</name></author><author><name sortKey="Seufferlein, T" uniqKey="Seufferlein T">T Seufferlein</name></author><author><name sortKey="Freier, W" uniqKey="Freier W">W Freier</name></author><author><name sortKey="Kretzschmar, A" uniqKey="Kretzschmar A">A Kretzschmar</name></author><author><name sortKey="Graeven, U" uniqKey="Graeven U">U Graeven</name></author><author><name sortKey="Grothey, A" uniqKey="Grothey A">A Grothey</name></author><author><name sortKey="Hinke, A" uniqKey="Hinke A">A Hinke</name></author><author><name sortKey="Schmiegel, W" uniqKey="Schmiegel W">W Schmiegel</name></author><author><name sortKey="Schmoll, Hj" uniqKey="Schmoll H">HJ Schmoll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saltz, Lb" uniqKey="Saltz L">LB Saltz</name></author><author><name sortKey="Clarke, S" uniqKey="Clarke S">S Clarke</name></author><author><name sortKey="Diaz Rubio, E" uniqKey="Diaz Rubio E">E Díaz-Rubio</name></author><author><name sortKey="Scheithauer, W" uniqKey="Scheithauer W">W Scheithauer</name></author><author><name sortKey="Figer, A" uniqKey="Figer A">A Figer</name></author><author><name sortKey="Wong, R" uniqKey="Wong R">R Wong</name></author><author><name sortKey="Koski, S" uniqKey="Koski S">S Koski</name></author><author><name sortKey="Lichinitser, M" uniqKey="Lichinitser M">M Lichinitser</name></author><author><name sortKey="Yang, Ts" uniqKey="Yang T">TS Yang</name></author><author><name sortKey="Rivera, F" uniqKey="Rivera F">F Rivera</name></author><author><name sortKey="Couture, F" uniqKey="Couture F">F Couture</name></author><author><name sortKey="Sirzen, F" uniqKey="Sirzen F">F Sirzén</name></author><author><name sortKey="Cassidy, J" uniqKey="Cassidy J">J Cassidy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falcone, A" uniqKey="Falcone A">A Falcone</name></author><author><name sortKey="Ricci, S" uniqKey="Ricci S">S Ricci</name></author><author><name sortKey="Brunetti, I" uniqKey="Brunetti I">I Brunetti</name></author><author><name sortKey="Pfanner, E" uniqKey="Pfanner E">E Pfanner</name></author><author><name sortKey="Allegrini, G" uniqKey="Allegrini G">G Allegrini</name></author><author><name sortKey="Barbara, C" uniqKey="Barbara C">C Barbara</name></author><author><name sortKey="Crin, L" uniqKey="Crin L">L Crinò</name></author><author><name sortKey="Benedetti, G" uniqKey="Benedetti G">G Benedetti</name></author><author><name sortKey="Evangelista, W" uniqKey="Evangelista W">W Evangelista</name></author><author><name sortKey="Fanchini, L" uniqKey="Fanchini L">L Fanchini</name></author><author><name sortKey="Cortesi, E" uniqKey="Cortesi E">E Cortesi</name></author><author><name sortKey="Picone, V" uniqKey="Picone V">V Picone</name></author><author><name sortKey="Vitello, S" uniqKey="Vitello S">S Vitello</name></author><author><name sortKey="Chiara, S" uniqKey="Chiara S">S Chiara</name></author><author><name sortKey="Granetto, C" uniqKey="Granetto C">C Granetto</name></author><author><name sortKey="Porcile, G" uniqKey="Porcile G">G Porcile</name></author><author><name sortKey="Fioretto, L" uniqKey="Fioretto L">L Fioretto</name></author><author><name sortKey="Orlandini, C" uniqKey="Orlandini C">C Orlandini</name></author><author><name sortKey="Andreuccetti, M" uniqKey="Andreuccetti M">M Andreuccetti</name></author><author><name sortKey="Masi, G" uniqKey="Masi G">G Masi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeh, Hj" uniqKey="Zeh H">HJ Zeh</name></author><author><name sortKey="Brown, Ck" uniqKey="Brown C">CK Brown</name></author><author><name sortKey="Holtzman, Mp" uniqKey="Holtzman M">MP Holtzman</name></author><author><name sortKey="Egorin, Mj" uniqKey="Egorin M">MJ Egorin</name></author><author><name sortKey="Holleran, Jl" uniqKey="Holleran J">JL Holleran</name></author><author><name sortKey="Potter, Dm" uniqKey="Potter D">DM Potter</name></author><author><name sortKey="Bartlett, Dl" uniqKey="Bartlett D">DL Bartlett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceelen, Wp" uniqKey="Ceelen W">WP Ceelen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siddik, Zh" uniqKey="Siddik Z">ZH Siddik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chong, G" uniqKey="Chong G">G Chong</name></author><author><name sortKey="Dickson, Jl" uniqKey="Dickson J">JL Dickson</name></author><author><name sortKey="Cunningham, D" uniqKey="Cunningham D">D Cunningham</name></author><author><name sortKey="Norman, Ar" uniqKey="Norman A">AR Norman</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name></author><author><name sortKey="Hill, Me" uniqKey="Hill M">ME Hill</name></author><author><name sortKey="Price, Tj" uniqKey="Price T">TJ Price</name></author><author><name sortKey="Oates, J" uniqKey="Oates J">J Oates</name></author><author><name sortKey="Tebbutt, N" uniqKey="Tebbutt N">N Tebbutt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanabe, M" uniqKey="Tanabe M">M Tanabe</name></author><author><name sortKey="Ito, Y" uniqKey="Ito Y">Y Ito</name></author><author><name sortKey="Tokudome, N" uniqKey="Tokudome N">N Tokudome</name></author><author><name sortKey="Sugihara, T" uniqKey="Sugihara T">T Sugihara</name></author><author><name sortKey="Miura, H" uniqKey="Miura H">H Miura</name></author><author><name sortKey="Takahashi, S" uniqKey="Takahashi S">S Takahashi</name></author><author><name sortKey="Seto, Y" uniqKey="Seto Y">Y Seto</name></author><author><name sortKey="Iwase, T" uniqKey="Iwase T">T Iwase</name></author><author><name sortKey="Hatake, K" uniqKey="Hatake K">K Hatake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berghmans, T" uniqKey="Berghmans T">T Berghmans</name></author><author><name sortKey="Gourcerol, D" uniqKey="Gourcerol D">D Gourcerol</name></author><author><name sortKey="Lafitte, Jj" uniqKey="Lafitte J">JJ Lafitte</name></author><author><name sortKey="Kotsori, K" uniqKey="Kotsori K">K Kotsori</name></author><author><name sortKey="Paesmans, M" uniqKey="Paesmans M">M Paesmans</name></author><author><name sortKey="Scherpereel, A" uniqKey="Scherpereel A">A Scherpereel</name></author><author><name sortKey="Leclercq, N" uniqKey="Leclercq N">N Leclercq</name></author><author><name sortKey="Sculier, Jp" uniqKey="Sculier J">JP Sculier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horvath, A" uniqKey="Horvath A">A Horvath</name></author><author><name sortKey="Mostafid, H" uniqKey="Mostafid H">H Mostafid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iyer, Vn" uniqKey="Iyer V">VN Iyer</name></author><author><name sortKey="Szybalski, W" uniqKey="Szybalski W">W Szybalski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iyer, Vn" uniqKey="Iyer V">VN Iyer</name></author><author><name sortKey="Szybalski, W" uniqKey="Szybalski W">W Szybalski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, Sk" uniqKey="Carter S">SK Carter</name></author><author><name sortKey="Comis, Rl" uniqKey="Comis R">RL Comis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whittington, Rm" uniqKey="Whittington R">RM Whittington</name></author><author><name sortKey="Close, Hp" uniqKey="Close H">HP Close</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, Sk" uniqKey="Carter S">SK Carter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Ge" uniqKey="Moore G">GE Moore</name></author><author><name sortKey="Bross, Id" uniqKey="Bross I">ID Bross</name></author><author><name sortKey="Ausmans, R" uniqKey="Ausmans R">R Ausmans</name></author><author><name sortKey="Nadler, S" uniqKey="Nadler S">S Nadler</name></author><author><name sortKey="Jones, R" uniqKey="Jones R">R Jones</name></author><author><name sortKey="Slack, N" uniqKey="Slack N">N Slack</name></author><author><name sortKey="Rimm, Aa" uniqKey="Rimm A">AA Rimm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kano, Y" uniqKey="Kano Y">Y Kano</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author><author><name sortKey="Akutsu, M" uniqKey="Akutsu M">M Akutsu</name></author><author><name sortKey="Suda, K" uniqKey="Suda K">K Suda</name></author><author><name sortKey="Inoue, Y" uniqKey="Inoue Y">Y Inoue</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author><author><name sortKey="Sakamoto, S" uniqKey="Sakamoto S">S Sakamoto</name></author><author><name sortKey="Miura, Y" uniqKey="Miura Y">Y Miura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sawada, N" uniqKey="Sawada N">N Sawada</name></author><author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name></author><author><name sortKey="Fukase, Y" uniqKey="Fukase Y">Y Fukase</name></author><author><name sortKey="Nishida, M" uniqKey="Nishida M">M Nishida</name></author><author><name sortKey="Yoshikubo, T" uniqKey="Yoshikubo T">T Yoshikubo</name></author><author><name sortKey="Ishitsuka, H" uniqKey="Ishitsuka H">H Ishitsuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franchi, F" uniqKey="Franchi F">F Franchi</name></author><author><name sortKey="Barone, C" uniqKey="Barone C">C Barone</name></author><author><name sortKey="Seminara, P" uniqKey="Seminara P">P Seminara</name></author><author><name sortKey="Codacci Pisanelli, G" uniqKey="Codacci Pisanelli G">G Codacci-Pisanelli</name></author><author><name sortKey="Codacci Pisanelli, M" uniqKey="Codacci Pisanelli M">M Codacci-Pisanelli</name></author><author><name sortKey="Ferri, Gm" uniqKey="Ferri G">GM Ferri</name></author><author><name sortKey="Garufi, C" uniqKey="Garufi C">C Garufi</name></author><author><name sortKey="Grieco, A" uniqKey="Grieco A">A Grieco</name></author><author><name sortKey="Pagani, V" uniqKey="Pagani V">V Pagani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, G" uniqKey="Pan G">G Pan</name></author><author><name sortKey="O Ourke, K" uniqKey="O Ourke K">K O’Rourke</name></author><author><name sortKey="Chinnaiyan, Am" uniqKey="Chinnaiyan A">AM Chinnaiyan</name></author><author><name sortKey="Gentz, R" uniqKey="Gentz R">R Gentz</name></author><author><name sortKey="Ebner, R" uniqKey="Ebner R">R Ebner</name></author><author><name sortKey="Ni, J" uniqKey="Ni J">J Ni</name></author><author><name sortKey="Dixit, Vm" uniqKey="Dixit V">VM Dixit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, G" uniqKey="Pan G">G Pan</name></author><author><name sortKey="Ni, J" uniqKey="Ni J">J Ni</name></author><author><name sortKey="Wei, Yf" uniqKey="Wei Y">YF Wei</name></author><author><name sortKey="Yu, G" uniqKey="Yu G">G Yu</name></author><author><name sortKey="Gentz, R" uniqKey="Gentz R">R Gentz</name></author><author><name sortKey="Dixit, Vm" uniqKey="Dixit V">VM Dixit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, P" uniqKey="Schneider P">P Schneider</name></author><author><name sortKey="Thome, M" uniqKey="Thome M">M Thome</name></author><author><name sortKey="Burns, K" uniqKey="Burns K">K Burns</name></author><author><name sortKey="Bodmer, Jl" uniqKey="Bodmer J">JL Bodmer</name></author><author><name sortKey="Hofmann, K" uniqKey="Hofmann K">K Hofmann</name></author><author><name sortKey="Kataoka, T" uniqKey="Kataoka T">T Kataoka</name></author><author><name sortKey="Holler, N" uniqKey="Holler N">N Holler</name></author><author><name sortKey="Tschopp, J" uniqKey="Tschopp J">J Tschopp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaudhary, Pm" uniqKey="Chaudhary P">PM Chaudhary</name></author><author><name sortKey="Eby, M" uniqKey="Eby M">M Eby</name></author><author><name sortKey="Jasmin, A" uniqKey="Jasmin A">A Jasmin</name></author><author><name sortKey="Bookwalter, A" uniqKey="Bookwalter A">A Bookwalter</name></author><author><name sortKey="Murray, J" uniqKey="Murray J">J Murray</name></author><author><name sortKey="Hood, L" uniqKey="Hood L">L Hood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walczak, H" uniqKey="Walczak H">H Walczak</name></author><author><name sortKey="Degli Esposti, Ma" uniqKey="Degli Esposti M">MA Degli-Esposti</name></author><author><name sortKey="Johnson, Rs" uniqKey="Johnson R">RS Johnson</name></author><author><name sortKey="Smolak, Pj" uniqKey="Smolak P">PJ Smolak</name></author><author><name sortKey="Waugh, Jy" uniqKey="Waugh J">JY Waugh</name></author><author><name sortKey="Boiani, N" uniqKey="Boiani N">N Boiani</name></author><author><name sortKey="Timour, Ms" uniqKey="Timour M">MS Timour</name></author><author><name sortKey="Gerhart, Mj" uniqKey="Gerhart M">MJ Gerhart</name></author><author><name sortKey="Schooley, Ka" uniqKey="Schooley K">KA Schooley</name></author><author><name sortKey="Smith, Ca" uniqKey="Smith C">CA Smith</name></author><author><name sortKey="Goodwin, Rg" uniqKey="Goodwin R">RG Goodwin</name></author><author><name sortKey="Rauch, Ct" uniqKey="Rauch C">CT Rauch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Gs" uniqKey="Wu G">GS Wu</name></author><author><name sortKey="Burns, Tf" uniqKey="Burns T">TF Burns</name></author><author><name sortKey="Mcdonald, Er" uniqKey="Mcdonald E">ER McDonald</name></author><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Meng, R" uniqKey="Meng R">R Meng</name></author><author><name sortKey="Krantz, Id" uniqKey="Krantz I">ID Krantz</name></author><author><name sortKey="Kao, G" uniqKey="Kao G">G Kao</name></author><author><name sortKey="Gan, Dd" uniqKey="Gan D">DD Gan</name></author><author><name sortKey="Zhou, Jy" uniqKey="Zhou J">JY Zhou</name></author><author><name sortKey="Muschel, R" uniqKey="Muschel R">R Muschel</name></author><author><name sortKey="Hamilton, Sr" uniqKey="Hamilton S">SR Hamilton</name></author><author><name sortKey="Spinner, Nb" uniqKey="Spinner N">NB Spinner</name></author><author><name sortKey="Markowitz, S" uniqKey="Markowitz S">S Markowitz</name></author><author><name sortKey="Wu, G" uniqKey="Wu G">G Wu</name></author><author><name sortKey="El Deiry, Ws" uniqKey="El Deiry W">WS el-Deiry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiley, Sr" uniqKey="Wiley S">SR Wiley</name></author><author><name sortKey="Schooley, K" uniqKey="Schooley K">K Schooley</name></author><author><name sortKey="Smolak, Pj" uniqKey="Smolak P">PJ Smolak</name></author><author><name sortKey="Din, Ws" uniqKey="Din W">WS Din</name></author><author><name sortKey="Huang, Cp" uniqKey="Huang C">CP Huang</name></author><author><name sortKey="Nicholl, Jk" uniqKey="Nicholl J">JK Nicholl</name></author><author><name sortKey="Sutherland, Gr" uniqKey="Sutherland G">GR Sutherland</name></author><author><name sortKey="Smith, Td" uniqKey="Smith T">TD Smith</name></author><author><name sortKey="Rauch, C" uniqKey="Rauch C">C Rauch</name></author><author><name sortKey="Smith, Ca" uniqKey="Smith C">CA Smith</name></author><author><name sortKey="Goodwin, Rg" uniqKey="Goodwin R">RG Goodwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffith, Ts" uniqKey="Griffith T">TS Griffith</name></author><author><name sortKey="Lynch, Dh" uniqKey="Lynch D">DH Lynch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lacour, S" uniqKey="Lacour S">S Lacour</name></author><author><name sortKey="Hammann, A" uniqKey="Hammann A">A Hammann</name></author><author><name sortKey="Wotawa, A" uniqKey="Wotawa A">A Wotawa</name></author><author><name sortKey="Corcos, L" uniqKey="Corcos L">L Corcos</name></author><author><name sortKey="Solary, E" uniqKey="Solary E">E Solary</name></author><author><name sortKey="Dimanche Boitrel, Mt" uniqKey="Dimanche Boitrel M">MT Dimanche-Boitrel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keane, Mm" uniqKey="Keane M">MM Keane</name></author><author><name sortKey="Ettenberg, Sa" uniqKey="Ettenberg S">SA Ettenberg</name></author><author><name sortKey="Nau, Mm" uniqKey="Nau M">MM Nau</name></author><author><name sortKey="Russell, Ek" uniqKey="Russell E">EK Russell</name></author><author><name sortKey="Lipkowitz, S" uniqKey="Lipkowitz S">S Lipkowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagane, M" uniqKey="Nagane M">M Nagane</name></author><author><name sortKey="Pan, G" uniqKey="Pan G">G Pan</name></author><author><name sortKey="Weddle, Jj" uniqKey="Weddle J">JJ Weddle</name></author><author><name sortKey="Dixit, Vm" uniqKey="Dixit V">VM Dixit</name></author><author><name sortKey="Cavenee, Wk" uniqKey="Cavenee W">WK Cavenee</name></author><author><name sortKey="Huang, Hj" uniqKey="Huang H">HJ Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Sb" uniqKey="Gibson S">SB Gibson</name></author><author><name sortKey="Oyer, R" uniqKey="Oyer R">R Oyer</name></author><author><name sortKey="Spalding, Ac" uniqKey="Spalding A">AC Spalding</name></author><author><name sortKey="Anderson, Sm" uniqKey="Anderson S">SM Anderson</name></author><author><name sortKey="Johnson, Gl" uniqKey="Johnson G">GL Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Tr" uniqKey="Singh T">TR Singh</name></author><author><name sortKey="Shankar, S" uniqKey="Shankar S">S Shankar</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Asim, M" uniqKey="Asim M">M Asim</name></author><author><name sortKey="Srivastava, Rk" uniqKey="Srivastava R">RK Srivastava</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asakuma, J" uniqKey="Asakuma J">J Asakuma</name></author><author><name sortKey="Sumitomo, M" uniqKey="Sumitomo M">M Sumitomo</name></author><author><name sortKey="Asano, T" uniqKey="Asano T">T Asano</name></author><author><name sortKey="Hayakawa, M" uniqKey="Hayakawa M">M Hayakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stuckey, Dw" uniqKey="Stuckey D">DW Stuckey</name></author><author><name sortKey="Shah, K" uniqKey="Shah K">K Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, J" uniqKey="Yoo J">J Yoo</name></author><author><name sortKey="Kim, Hr" uniqKey="Kim H">HR Kim</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, J" uniqKey="Yoo J">J Yoo</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Kim, Hc" uniqKey="Kim H">HC Kim</name></author><author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name></author><author><name sortKey="Basse, P" uniqKey="Basse P">P Basse</name></author><author><name sortKey="Park, Bh" uniqKey="Park B">BH Park</name></author><author><name sortKey="Lee, Bc" uniqKey="Lee B">BC Lee</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dewey, Wc" uniqKey="Dewey W">WC Dewey</name></author><author><name sortKey="Sapareto, Sa" uniqKey="Sapareto S">SA Sapareto</name></author><author><name sortKey="Betten, Da" uniqKey="Betten D">DA Betten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holahan, Ev" uniqKey="Holahan E">EV Holahan</name></author><author><name sortKey="Highfield, Dp" uniqKey="Highfield D">DP Highfield</name></author><author><name sortKey="Holahan, Pk" uniqKey="Holahan P">PK Holahan</name></author><author><name sortKey="Dewey, Wc" uniqKey="Dewey W">WC Dewey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kampinga, Hh" uniqKey="Kampinga H">HH Kampinga</name></author><author><name sortKey="Dikomey, E" uniqKey="Dikomey E">E Dikomey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haas, Gp" uniqKey="Haas G">GP Haas</name></author><author><name sortKey="Klugo, Rc" uniqKey="Klugo R">RC Klugo</name></author><author><name sortKey="Hetzel, Fw" uniqKey="Hetzel F">FW Hetzel</name></author><author><name sortKey="Barton, Ee" uniqKey="Barton E">EE Barton</name></author><author><name sortKey="Cerny, Jc" uniqKey="Cerny J">JC Cerny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herman, Ts" uniqKey="Herman T">TS Herman</name></author><author><name sortKey="Sweets, Cc" uniqKey="Sweets C">CC Sweets</name></author><author><name sortKey="White, Dm" uniqKey="White D">DM White</name></author><author><name sortKey="Gerner, Ew" uniqKey="Gerner E">EW Gerner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ko, Sh" uniqKey="Ko S">SH Ko</name></author><author><name sortKey="Ueno, T" uniqKey="Ueno T">T Ueno</name></author><author><name sortKey="Yoshimoto, Y" uniqKey="Yoshimoto Y">Y Yoshimoto</name></author><author><name sortKey="Yoo, Js" uniqKey="Yoo J">JS Yoo</name></author><author><name sortKey="Abdel Wahab, Oi" uniqKey="Abdel Wahab O">OI Abdel-Wahab</name></author><author><name sortKey="Abdel Wahab, Z" uniqKey="Abdel Wahab Z">Z Abdel-Wahab</name></author><author><name sortKey="Chu, E" uniqKey="Chu E">E Chu</name></author><author><name sortKey="Pruitt, Sk" uniqKey="Pruitt S">SK Pruitt</name></author><author><name sortKey="Friedman, Hs" uniqKey="Friedman H">HS Friedman</name></author><author><name sortKey="Dewhirst, Mw" uniqKey="Dewhirst M">MW Dewhirst</name></author><author><name sortKey="Tyler, Ds" uniqKey="Tyler D">DS Tyler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name></author><author><name sortKey="Lagasse, E" uniqKey="Lagasse E">E Lagasse</name></author><author><name sortKey="Kwon, Yt" uniqKey="Kwon Y">YT Kwon</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krueger, A" uniqKey="Krueger A">A Krueger</name></author><author><name sortKey="Schmitz, I" uniqKey="Schmitz I">I Schmitz</name></author><author><name sortKey="Baumann, S" uniqKey="Baumann S">S Baumann</name></author><author><name sortKey="Krammer, Ph" uniqKey="Krammer P">PH Krammer</name></author><author><name sortKey="Kirchhoff, S" uniqKey="Kirchhoff S">S Kirchhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kober, Am" uniqKey="Kober A">AM Kober</name></author><author><name sortKey="Legewie, S" uniqKey="Legewie S">S Legewie</name></author><author><name sortKey="Pforr, C" uniqKey="Pforr C">C Pforr</name></author><author><name sortKey="Fricker, N" uniqKey="Fricker N">N Fricker</name></author><author><name sortKey="Eils, R" uniqKey="Eils R">R Eils</name></author><author><name sortKey="Krammer, Ph" uniqKey="Krammer P">PH Krammer</name></author><author><name sortKey="Lavrik, In" uniqKey="Lavrik I">IN Lavrik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parrish, Ab" uniqKey="Parrish A">AB Parrish</name></author><author><name sortKey="Freel, Cd" uniqKey="Freel C">CD Freel</name></author><author><name sortKey="Kornbluth, S" uniqKey="Kornbluth S">S Kornbluth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiaofeng, W" uniqKey="Xiaofeng W">W Xiaofeng</name></author><author><name sortKey="Yukai, H" uniqKey="Yukai H">H Yukai</name></author><author><name sortKey="Louis, Df" uniqKey="Louis D">DF Louis</name></author><author><name sortKey="Kam, Mh" uniqKey="Kam M">MH Kam</name></author><author><name sortKey="Leaf, H" uniqKey="Leaf H">H Leaf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, K" uniqKey="Shah K">K Shah</name></author><author><name sortKey="Tung, Ch" uniqKey="Tung C">CH Tung</name></author><author><name sortKey="Yang, K" uniqKey="Yang K">K Yang</name></author><author><name sortKey="Weissleder, R" uniqKey="Weissleder R">R Weissleder</name></author><author><name sortKey="Breakefield, Xo" uniqKey="Breakefield X">XO Breakefield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hardy, S" uniqKey="Hardy S">S Hardy</name></author><author><name sortKey="Kitamura, M" uniqKey="Kitamura M">M Kitamura</name></author><author><name sortKey="Harris Stansil, T" uniqKey="Harris Stansil T">T Harris-Stansil</name></author><author><name sortKey="Dai, U" uniqKey="Dai U">U Dai</name></author><author><name sortKey="Phipps, Ml" uniqKey="Phipps M">ML Phipps</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name></author><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Bartlett, Dl" uniqKey="Bartlett D">DL Bartlett</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wirawan, E" uniqKey="Wirawan E">E Wirawan</name></author><author><name sortKey="Vande Walle, L" uniqKey="Vande Walle L">L Vande Walle</name></author><author><name sortKey="Kersse, K" uniqKey="Kersse K">K Kersse</name></author><author><name sortKey="Cornelis, S" uniqKey="Cornelis S">S Cornelis</name></author><author><name sortKey="Claerhout, S" uniqKey="Claerhout S">S Claerhout</name></author><author><name sortKey="Vanoverberghe, I" uniqKey="Vanoverberghe I">I Vanoverberghe</name></author><author><name sortKey="Roelandt, R" uniqKey="Roelandt R">R Roelandt</name></author><author><name sortKey="De Rycke, R" uniqKey="De Rycke R">R De Rycke</name></author><author><name sortKey="Verspurten, J" uniqKey="Verspurten J">J Verspurten</name></author><author><name sortKey="Declercq, W" uniqKey="Declercq W">W Declercq</name></author><author><name sortKey="Agostinis, P" uniqKey="Agostinis P">P Agostinis</name></author><author><name sortKey="Vanden Berghe, T" uniqKey="Vanden Berghe T">T Vanden Berghe</name></author><author><name sortKey="Lippens, S" uniqKey="Lippens S">S Lippens</name></author><author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author><author><name sortKey="Sun, Q" uniqKey="Sun Q">Q Sun</name></author><author><name sortKey="Ding, Wx" uniqKey="Ding W">WX Ding</name></author><author><name sortKey="Yin, Xm" uniqKey="Yin X">XM Yin</name></author><author><name sortKey="Sobol, Rw" uniqKey="Sobol R">RW Sobol</name></author><author><name sortKey="Stolz, Db" uniqKey="Stolz D">DB Stolz</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itakura, E" uniqKey="Itakura E">E Itakura</name></author><author><name sortKey="Kishi, C" uniqKey="Kishi C">C Kishi</name></author><author><name sortKey="Inoue, K" uniqKey="Inoue K">K Inoue</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iijima, K" uniqKey="Iijima K">K Iijima</name></author><author><name sortKey="Ohara, M" uniqKey="Ohara M">M Ohara</name></author><author><name sortKey="Seki, R" uniqKey="Seki R">R Seki</name></author><author><name sortKey="Tauchi, H" uniqKey="Tauchi H">H Tauchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayashi, N" uniqKey="Hayashi N">N Hayashi</name></author><author><name sortKey="Kobayashi, M" uniqKey="Kobayashi M">M Kobayashi</name></author><author><name sortKey="Shamma, A" uniqKey="Shamma A">A Shamma</name></author><author><name sortKey="Morimura, Y" uniqKey="Morimura Y">Y Morimura</name></author><author><name sortKey="Takahashi, C" uniqKey="Takahashi C">C Takahashi</name></author><author><name sortKey="Yamamoto, K" uniqKey="Yamamoto K">K Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kharbanda, S" uniqKey="Kharbanda S">S Kharbanda</name></author><author><name sortKey="Ren, R" uniqKey="Ren R">R Ren</name></author><author><name sortKey="Pandey, P" uniqKey="Pandey P">P Pandey</name></author><author><name sortKey="Shafman, Td" uniqKey="Shafman T">TD Shafman</name></author><author><name sortKey="Feller, Sm" uniqKey="Feller S">SM Feller</name></author><author><name sortKey="Weichselbaum, Rr" uniqKey="Weichselbaum R">RR Weichselbaum</name></author><author><name sortKey="Kufe, Dw" uniqKey="Kufe D">DW Kufe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Bd" uniqKey="Price B">BD Price</name></author><author><name sortKey="Hughes Davies, L" uniqKey="Hughes Davies L">L Hughes-Davies</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milne, Dm" uniqKey="Milne D">DM Milne</name></author><author><name sortKey="Palmer, Rh" uniqKey="Palmer R">RH Palmer</name></author><author><name sortKey="Campbell, Dg" uniqKey="Campbell D">DG Campbell</name></author><author><name sortKey="Meek, Dw" uniqKey="Meek D">DW Meek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, Sr" uniqKey="Hall S">SR Hall</name></author><author><name sortKey="Campbell, Le" uniqKey="Campbell L">LE Campbell</name></author><author><name sortKey="Meek, Dw" uniqKey="Meek D">DW Meek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baudier, J" uniqKey="Baudier J">J Baudier</name></author><author><name sortKey="Delphin, C" uniqKey="Delphin C">C Delphin</name></author><author><name sortKey="Grunwald, D" uniqKey="Grunwald D">D Grunwald</name></author><author><name sortKey="Khochbin, S" uniqKey="Khochbin S">S Khochbin</name></author><author><name sortKey="Lawrence, Jj" uniqKey="Lawrence J">JJ Lawrence</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milne, Dm" uniqKey="Milne D">DM Milne</name></author><author><name sortKey="Campbell, Dg" uniqKey="Campbell D">DG Campbell</name></author><author><name sortKey="Caudwell, Fb" uniqKey="Caudwell F">FB Caudwell</name></author><author><name sortKey="Meek, Dw" uniqKey="Meek D">DW Meek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milne, Dm" uniqKey="Milne D">DM Milne</name></author><author><name sortKey="Campbell, Le" uniqKey="Campbell L">LE Campbell</name></author><author><name sortKey="Campbell, Dg" uniqKey="Campbell D">DG Campbell</name></author><author><name sortKey="Meek, Dw" uniqKey="Meek D">DW Meek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jamal, S" uniqKey="Jamal S">S Jamal</name></author><author><name sortKey="Ziff, Eb" uniqKey="Ziff E">EB Ziff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shieh, Sy" uniqKey="Shieh S">SY Shieh</name></author><author><name sortKey="Ikeda, M" uniqKey="Ikeda M">M Ikeda</name></author><author><name sortKey="Taya, Y" uniqKey="Taya Y">Y Taya</name></author><author><name sortKey="Prives, C" uniqKey="Prives C">C Prives</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tibbetts, Rs" uniqKey="Tibbetts R">RS Tibbetts</name></author><author><name sortKey="Brumbaugh, Km" uniqKey="Brumbaugh K">KM Brumbaugh</name></author><author><name sortKey="Williams, Jm" uniqKey="Williams J">JM Williams</name></author><author><name sortKey="Sarkaria, Jn" uniqKey="Sarkaria J">JN Sarkaria</name></author><author><name sortKey="Cliby, Wa" uniqKey="Cliby W">WA Cliby</name></author><author><name sortKey="Shieh, Sy" uniqKey="Shieh S">SY Shieh</name></author><author><name sortKey="Taya, Y" uniqKey="Taya Y">Y Taya</name></author><author><name sortKey="Prives, C" uniqKey="Prives C">C Prives</name></author><author><name sortKey="Abraham, Rt" uniqKey="Abraham R">RT Abraham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alcala, Ma" uniqKey="Alcala M">MA Alcala</name></author><author><name sortKey="Park, K" uniqKey="Park K">K Park</name></author><author><name sortKey="Yoo, J" uniqKey="Yoo J">J Yoo</name></author><author><name sortKey="Lee, Dh" uniqKey="Lee D">DH Lee</name></author><author><name sortKey="Park, Bh" uniqKey="Park B">BH Park</name></author><author><name sortKey="Lee, Bc" uniqKey="Lee B">BC Lee</name></author><author><name sortKey="Bartlett, Dl" uniqKey="Bartlett D">DL Bartlett</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Bk" uniqKey="Sun B">BK Sun</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Nguyen, Hn" uniqKey="Nguyen H">HN Nguyen</name></author><author><name sortKey="Oh, S" uniqKey="Oh S">S Oh</name></author><author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name></author><author><name sortKey="Choi, Hj" uniqKey="Choi H">HJ Choi</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Kim, Sy" uniqKey="Kim S">SY Kim</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ubersax, Ja" uniqKey="Ubersax J">JA Ubersax</name></author><author><name sortKey="Ferrell, Je" uniqKey="Ferrell J">JE Ferrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basu, A" uniqKey="Basu A">A Basu</name></author><author><name sortKey="Haldar, S" uniqKey="Haldar S">S Haldar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kharbanda, S" uniqKey="Kharbanda S">S Kharbanda</name></author><author><name sortKey="Saxena, S" uniqKey="Saxena S">S Saxena</name></author><author><name sortKey="Yoshida, K" uniqKey="Yoshida K">K Yoshida</name></author><author><name sortKey="Pandey, P" uniqKey="Pandey P">P Pandey</name></author><author><name sortKey="Kaneki, M" uniqKey="Kaneki M">M Kaneki</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Cheng, K" uniqKey="Cheng K">K Cheng</name></author><author><name sortKey="Chen, Yn" uniqKey="Chen Y">YN Chen</name></author><author><name sortKey="Campbell, A" uniqKey="Campbell A">A Campbell</name></author><author><name sortKey="Sudha, T" uniqKey="Sudha T">T Sudha</name></author><author><name sortKey="Yuan, Zm" uniqKey="Yuan Z">ZM Yuan</name></author><author><name sortKey="Narula, J" uniqKey="Narula J">J Narula</name></author><author><name sortKey="Weichselbaum, R" uniqKey="Weichselbaum R">R Weichselbaum</name></author><author><name sortKey="Nalin, C" uniqKey="Nalin C">C Nalin</name></author><author><name sortKey="Kufe, D" uniqKey="Kufe D">D Kufe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Pattingre, S" uniqKey="Pattingre S">S Pattingre</name></author><author><name sortKey="Sinha, S" uniqKey="Sinha S">S Sinha</name></author><author><name sortKey="Bassik, M" uniqKey="Bassik M">M Bassik</name></author><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Pennsylvanie</li><li>Région capitale de Séoul</li></region><settlement><li>Pittsburgh</li><li>Séoul</li></settlement><orgName><li>Université de Pittsburgh</li><li>Université nationale de Séoul</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Kim, Seog Young" sort="Kim, Seog Young" uniqKey="Kim S" first="Seog-Young" last="Kim">Seog-Young Kim</name></region><name sortKey="Bartlett, David L" sort="Bartlett, David L" uniqKey="Bartlett D" first="David L." last="Bartlett">David L. Bartlett</name><name sortKey="Lee, Dae Hee" sort="Lee, Dae Hee" uniqKey="Lee D" first="Dae-Hee" last="Lee">Dae-Hee Lee</name><name sortKey="Lee, Yong J" sort="Lee, Yong J" uniqKey="Lee Y" first="Yong J." last="Lee">Yong J. Lee</name><name sortKey="Lee, Yong J" sort="Lee, Yong J" uniqKey="Lee Y" first="Yong J." last="Lee">Yong J. Lee</name><name sortKey="Song, Xinxin" sort="Song, Xinxin" uniqKey="Song X" first="Xinxin" last="Song">Xinxin Song</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kwon, Yong Tae" sort="Kwon, Yong Tae" uniqKey="Kwon Y" first="Yong Tae" last="Kwon">Yong Tae Kwon</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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